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Largest body of clinical evidence in PNS

More data means more informed decisions. The SPRINT® PNS System provides clinically proven pain relief supported by the largest body of clinical evidence in PNS.

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20+

Published or ongoing prospective clinical studies1-18

100+

Peer-reviewed publications

$40M+

DoD and NIH funding to support research

Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain

This double-blinded, placebo-controlled RCT demonstrated significant pain relief and improved function with PNS for postoperative knee pain at the end of treatment (EOT) and 1-month after EOT.

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Charts for study Charts for study

Valimahomed 2024: RWE of PNS for Chronic Shoulder Pain

This retrospective analysis quantified improvements in multiple domains of health (e.g.,  sleep, physical function) at EOT among patients who received SPRINT for treatment of chronic shoulder pain. 

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Pritzlaff 2024: Review of Studies on PNS for Chronic Pain

This review summarizes findings from 10 prospective studies of PNS for chronic pain. Across all pain types included, patients reported substantial reductions in pain and/or pain interference with PNS.

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RCT

Randomized controlled trials (RCTs)

Backed by 7 successful RCTs, more than any other PNS System

SPRINT PNS is supported by clinical data from 7 successful RCTs, which have demonstrated clinically significant improvements in pain, functional outcomes, medication usage, and/or quality of life across a variety of pain conditions, such as: 

  • Shoulder Pain3, 5
  • Post-Amputation Pain12, 15
  • Post-Surgical Pain 14, 17
  • Low Back Pain19
70% graphic

Real-world evidence

Backed by the largest review of real-world PNS data.

The largest retrospective review of real-word PNS data of over 6,100 patients, with over 71% demonstrating significant pain relief and/or improvement in quality of life following 60-day percutaneous PNS treatment with the SPRINT PNS System.20* 

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*The total rate of medical events collected from the product complaint database was approximately 6%, with skin irritation due to adhesive components as the most reported event. 

References

  1. Yu D, et al. Arch Phys Med Rehabil. 2001; 82(1): 20-25.
  2. Renzenbrink G, et al. Clin Rehabil. 2004; 18(4): 359-365.
  3. Chae J, et al. Am J Phys Med Rehabil. 2005; 84(11): 832-842.
  4. Chae J, et al. Pain Pract. 2013; 13(1): 59-67.
  5. Wilson R, et al. Am J Phys Med Rehabil. 2014; 93(1): 17-28.
  6. Wilson R, et al. Neuromodulation. 2014; 17(8): 771-776.
  7. Rauck R, et al. Neuromodulation. 2014; 17(2): 188-197.
  8. Ilfeld B, et al. Pain Pract. 2017; 17(7): 892-901.
  9. Ilfeld B, et al. J Orthop Surg Res. 2017; 12(1): 4.
  10. Wilson R, et al. Neuromodulation. 2018; 21(3): 290-295.
  11. Ilfeld B, et al. Neuromodulation. 2019; 22(5): 653-660.
  12. Gilmore C, et al. Neuromodulation. 2019; 22(5): 615-620.
  13. Gilmore C, et al. Reg Anesth Pain Med. 2020; 45(1): 44-51.
  14. Ilfeld B, et al. Anesthesiology. 2021; 135: 95–110.
  15. Albright-Trainer B, et al. Pain Mgmt. 2022; 12(3): 357-369.
  16. Gilmore C, et al. Interv Pain Med. 2023; 2(2): 100243.
  17. Goree J, et al. Neuromodulation. 2024; 27(5): 47-861.
  18. Ongoing studies listed on ClinicalTrials.gov as of January 21, 2025.
  19. McCormick Z, et al. Poster from NANS Annual Meeting 2025.
  20. Huntoon M, et al. Pain Physician. 2023; 26: 273-281.