1. Home
  2. SPRINT PNS System
  3. Clinical Evidence
  4. Explore More

Explore the clinical evidence

View evidence archive

Clinical studies

View All
Gutierrez 2025: 60-Day PNS of the Occipital Nerves for Headache
Summary
  • Primary endpoint from a prospective study (n=20) shows headache relief after 60-day PNS
  • 85% of participants at end of treatment had at least 50% reductions in pain and/or pain interference
  • Ongoing follow-up indicates that relief is sustained in a majority of participants
Gilmore 2025: 4-Year Follow Up After 60-day PNS in Low Back Pain
Summary
  • Long-term follow-up survey for prior study shows outcomes in back pain 4 years after 60-day PNS
  • Majority of respondents reported sustained relief of back pain an average of 4.7 years after PNS
  • 70% avoided progression to more costly, invasive, and/or destructive low back pain interventions
Goree 2024: RCT of 60-Day PNS for Post-surgical TKA Pain
Summary
  • Multicenter RCT: 52 patients (41 in primary endpoint), 60-day PNS vs. sham for post-TKA pain.
  • Significant Primary Endpoint (≥50% pain relief at EOT): PNS, 60%,vs. Sham, 24% (p=0.028).
  • Significant improvements in function (walking distance), WOMAC, and PGIC QoL with PNS at EOT.

Real-world data

View All
Vorenkamp 2025: Shoulder Pain Follow-up Survey after 60-Day PNS
Summary
  • A majority of responders to 60-day PNS reported sustained shoulder pain relief in a follow-up survey
  • Through up to 5 years, over 80% avoided advancing to additional interventions for shoulder pain
  • A majority of patients interested in deferring shoulder surgery successfully did so after 60-day PNS
Gutierrez 2024: Chart Review of PNS for Chronic Shoulder Pain
Summary
  • Anonymized medical records were reviewed of patients who received SPRINT PNS for shoulder pain.
  • Over 80% of patients reported a substantial (≥50%) reduction in shoulder pain with SPRINT at EOT.
  • Bimodal stimulation produced the greatest percent pain relief.
Valimahomed 2024: RWE of PNS for Chronic Shoulder Pain
Summary
  • Retrospective Real World Evidence (RWE) analysis of 768 patients with chronic shoulder pain.
  • Common PNS lead targets included the suprascapular and/or axillary nerves.
  • Improvements in multiple health domains (e.g., quality of life, physicial function, sleep) at EOT.

Reviews & other publications

View All
Gill 2025: ASPN Consensus Guidelines for 60-day PNS
Summary
  • First clinical guideline specifically assessing the clinical use of 60-day PNS
  • 60-day PNS received received strong to moderate recommendations for several pain conditions
  • Strong recommendations  made in chronic back pain, postoperative knee pain, and post-amputation pain
Pritzlaff 2024: Review of Studies on PNS for Chronic Pain
Summary
  • Ten studies were identified that prospectively studied PNS for treatment of chronic pain.
  • The studies included patients with shoulder pain, neuropathic pain, or low back pain.
  • Reductions in pain and/or pain interference were consistently reported across all pain types.
Staats 2021: Surveys of Patient Preference for LBP Interventions
Summary
  • Study using two market research surveys of chronic pain patient preferences for LBP interventions.
  • LBP patients preferred temporary interventions to permanently implanted devices.
  • Temporary PNS was the most preferred treatment option over RFA and permanent implants.

Case reports

View All
Gutierrez 2024: PNS for CRPS Case Reports
Summary
  • SPRINT PNS was used to treat complex regional pain syndrome (CRPS).
  • Three cases of CRPS in the lower extremity with significant and sustained relief of pain.
  • These three cases suggest that 60-day PNS can be a safe and efficacious treatment for CRPS.
Tate 2023: Technical Case Report on PNS of Musculocutaneous Nerve
Summary
  • Completed ultrasound-guided placement of short-term PNS lead targeting musculocutaneous nerve (MCN)
  • Patient had total pain resolution & coverage in antecubital & radial forearm areas during 60-Day PNS
  • Ultrasound-guided placement of PNS is feasible for targeting the MCN in refractory elbow pain
Mach 2023: Case series of lumbar PNS for cancer-related back pain
Summary
  • PNS for pain secondary to myeloma-related spinal lesions enabled pain relief for radiation therapy
  • Lumbar medial branch PNS is a promising option for back pain from primary or metastatic tumors
  • Four patients successfully used lumbar PNS for pain relief, allowing them to complete radiation

Posters

View All